Investigation of antioxidant and antimicrobial properties of Centella asiatica L. extract in the northern region of the country

Document Type : Original Article

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Department of Chemistry, Ayatollah Amoli Branch, Islamic Azad University, Amol, Iran

10.22092/mpt.2024.365160.1142

Abstract

This study was performed to investigate the antimicrobial properties of Centella asiatica L. extract in the northern part of the country using the antimicrobial effects of hydroethanolic extract on Staphylococcus aureus, Escherichia coli, Salmonella typhimurium, Streptococcus Mutans and Aspergillus flavus and Candida albicans, as well as investigating free radical scavenging activities of DPPH, Total phenol and flavonoids were performed. The plant was collected from Shaft city in Gilan province and the extraction process was performed by Maceration method and distributed by solvent rotary apparatus and for the experiments, the antimicrobial and antioxidant activity in the extract increased with increasing concentration. Staphylococcus aureus and Aspergillus flavus had the most susceptible to plate water extract with minimum inhibitory and Bactericidal concentrations of 100 and 200 μg/ml. The average total phenol in the extract of this plant was equal to 1.469 mg GAE/g EXT and the average flavonoid was equal to 2.679 mg QE/g EXT of the medicinal plant dish water. In the study of free radical scavenging DPPH, concentrations of 400 μg / ml with an average of 94.89% and concentrations of 6.25 μg / ml with an average of 42.01% had the highest and lowest percentages of free radical scavenging, respectively.

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